Santa Croce is one of the historical florentine district: the church conserve the tombs of Michelangelo and Galileo and is one of the most important monument of Florence. The location is perfect to discover Florence and its treasures: Uffizi Gallery, Palazzo Vecchio, Duomo: everything is in a walking distance.
The district of Santa Croce is famous also for the nightlife: there are a lot of restaurants, bar and pub in the surroundings.
Close to Teatro della Pergola and Teatro Verdi, Il Poeta Dante is the perfect place to stay if you desire to attend a performance.